Reference-Based OCT Angiogram Super-Resolution With Learnable Texture Generation

Yuyan Ruan, Dawei Yang, Ziqi Tang, An Ran Ran, Jiguang Wang, Carol Y. Cheung, and Hao Chen
IEEE Transactions on Neural Networks and Learning Systems

Towards a generalizable pathology foundation model via unified knowledge distillation

Jiabo Ma, Zhengrui Guo, Fengtao Zhou, Yihui Wang, Yingxue Xu, Yu Cai, Zhengjie Zhu, Cheng Jin, Yi Lin, Xinrui Jiang, Anjia Han, Li Liang, Ronald Cheong Kin Chan, Jiguang Wang, Kwang-Ting Cheng, Hao Chen
arXiv preprint arXiv:2407.18449

A multimodal knowledge-enhanced whole-slide pathology foundation model

Yingxue Xu, Yihui Wang, Fengtao Zhou, Jiabo Ma, Shu Yang, Huangjing Lin, Xin Wang, Jiguang Wang, Li Liang, Anjia Han, Ronald Cheong Kin Chan, Hao Chen
arXiv preprint arXiv:2407.15362

Frequency-dependent selection of neoantigens fosters tumor immune escape and predicts immunotherapy response

Shaoqing Chen, Duo Xie, Zan Li, Jiguang Wang, Zheng Hu, Da Zhou
Communications Biology 7 (1), 770

Somatic PDGFRB activating variants promote smooth muscle cell phenotype modulation in intracranial fusiform aneurysm

Li Hao, Xiaolong Ya, Jiaye Wu, Chuming Tao, Ruochen Ma, Zhiyao Zheng, Siqi Mou, Yiming Ling, Yingxi Yang, Jiguang Wang, Yan Zhang, Qing Lin, Jizong Zhao
Journal of Biomedical Science 31 (1), 51

Foundation model for advancing healthcare: Challenges, opportunities, and future directions

Yuting He, Fuxiang Huang, Xinrui Jiang, Yuxiang Nie, Minghao Wang, Jiguang Wang, Hao Chen
IEEE Reviews in Biomedical Engineering

iMD4GC: Incomplete Multimodal Data Integration to Advance Precise Treatment Response Prediction and Survival Analysis for Gastric Cancer

Fengtao Zhou, Yingxue Xu, Yanfen Cui, Shenyan Zhang, Yun Zhu, Weiyang He, Jiguang Wang, Xin Wang, Ronald Chan, Louis Ho Shing Lau, Chu Han, Dafu Zhang, Zhenhui Li, Hao Chen
arXiv preprint arXiv:2404.01192.

Multimodal integration of single cell ATAC-seq data enables highly accurate delineation of clinically relevant tumor cell subpopulations

Kewei Xiong, Ruofan Ding, Yangmei Qin, Xudong Zou, Jiguang Wang, Chen Yu, Lei Li
bioRxiv, 2024.10. 11.617736

Enhanced clinical outcomes with radiotherapy in diagnostically challenging intracranial plasmacytomas: Analysis of 190 cases

Yuan Feng, Zongpu Zhang, Fufang Qiu, Zixiao Yang, Ji Xiong, Wei Zhu, Fangzhu Wan, Bobin Chen, Jiguang Wang, Yi Zhang#, Wei Hua#
Cancer Med. 2024; 13:e7017.

Genotype-phenotype correlations in multiple lesions of familial cerebral cavernous malformations concerning phosphatidylinositol 3-kinase catalytic subunit alpha mutations

Jie Wang, Jihong Tang, Yingxi Yang, Yuming Jiao, Ran Huo, Hongyuan Xu, Shaozhi Zhao, Yingfan Sun, Qiheng He, Qifeng Yu, Shuo Wang, Jizong Zhao, Jiguang Wang#, Yong Cao#
Clin. Transl. Med., 14: e1610.

Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma

Xing Cheng, Jing An, Jitong Lou, Qisheng Gu, Weimin Ding, Gaith Nabil Droby, Yilin Wang, Chenghao Wang, Yanzhe Gao, Jay Ramanlal Anand, Abigail Shelton, Andrew Benson Satterlee, Breanna Mann, Yun-Chung Hsiao, Chih-Wei Liu, Kun Lu, Shawn Hingtgen, Jiguang Wang, Zhaoliang Liu, C. Ryan Miller, Di Wu, Cyrus Vaziri & Yang Yang
Nature Communications 15, Article number: 1957 (2024)

A multi-ethnic germline-somatic association database deciphers multilayered and interconnected genetic mutations in cancer

Junyi Xin*, Zongchao Mo*, Ruichao Chai, Wei Hua, Jiguang Wang#.
Cancer Res (2024) 84 (3): 364–371.

Heterogenous driving genetic events contribute to the dissemination of choroid plexus papilloma

Yuan Feng, Hao Xu, Bo Pang, Xiaomu Hu, Jinsen Zhang, Xin Zhang, Xiaowen Wang, Yan Gong, Shenghan Peng, Ying Sun, Jiguang Wang, Wei Zhu, Wei Hua, Ying Mao.
Journal of Neuropathology & Experimental Neurology, Volume 83, Issue 2, February 2024, Pages 131–135

Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression

Rebecca J. Leeman-Neill*, Dong Song*, Jonathan Bizarro, Ludivine Wacheul, Gerson Rothschild, Sameer Singh, Yang Yang, Aditya Y. Sarode, Kishore Gollapalli, Lijing Wu, Wanwei Zhang, Yiyun Chen, Max C. Lauring, D. Eric Whisenant, Shweta Bhavsar, Junghyun Lim, Steven H. Swerdlow, Govind Bhagat, Qian Zhao, Luke E. Berchowitz, Denis L. J. Lafontaine, Jiguang Wang#, Uttiya Basu#.
Nature Genetics 55, pages 2160–2174 (2023)

Adaptive DNA amplification of synthetic gene circuit opens new way to overcome cancer chemoresistance

Yiming Wan*, Quanhua Mu*, Rafał Krzysztoń*, Joseph Cohen, Damiano Coraci, Christopher Helenek, Christopher Tompkins, Annie Lin, Kevin Farquhar, Erin Cross, Jiguang Wang, Gábor Balázsi.
PNAS, 120 (49) e2303114120

circRNADisease v2.0: an updated resource for high-quality experimentally supported circRNA-disease associations

Zhi-Yan Sun*, Chang-Lin Yang*, Li-Jie Huang*, Zong-Chao Mo*, Ke-Nan Zhang, Wen-Hua Fan, Kuan-Yu Wang, Fan Wu, Ji-Guang Wang, Fan-Lin Meng#, Zheng Zhao# and Tao Jiang#.
Nucleic Acids Research, 2023, 1-8

Identifying predictors of glioma evolution from longitudinal sequencing

Quanhua Mu*, Ruichao Chai*, Bo Pang, Yingxi Yang, Hanjie Liu, Zheng Zhao, Zhaoshi Bao, Dong Song, Zhihan Zhu, Mengli Yan, Biaobin Jiang, Zongchao Mo, Jihong Tang, Jason K. Sa, Hee Jin Cho, Yuzhou Chang, Kaitlin Hao Yi Chan, Danson Shek Chun Loi, Sindy Sing Ting Tam, Aden Ka Yin Chan, Angela Ruohao Wu, Zhaoqi Liu, Wai Sang Poon, Ho Keung Ng, Danny Tat Ming Chan, Antonio Iavarone#, Do-Hyun Nam#, Tao Jiang#, Jiguang Wang#.
Science Translational Medicine, 15, eadh4181 (2023)

Tumor-associated monocytes promote mesenchymal transformation through EGFR signaling in glioma

Yiyun Chen*, Ran Huo*, Weirong Kang*, Yuwei Liu*, Zheng Zhao*, Weilun Fu, Ruochen Ma, Xiaomeng Zhang, Jihong Tang, Zhihan Zhu, Qingyang Lyu, Yi Huang, Mengli Yan, Biaobin Jiang, Ruichao Chai, Zhaoshi Bao, Zheng Hu, Weiping Wang#, Tao Jiang#, Yong Cao#, Jiguang Wang#
Cell Reports Medicine, 4, 101177 (2023)

Somatic GJA4 Mutation in Intracranial Extra-axial Cavernous Hemangiomas

Ran Huo*, Yingxi Yang*, Hongyuan Xu*, Shaozhi Zhao, Dong Song, Jiancong Weng, Ruochen Ma, Yingfan Sun, Jie Wang, Yuming Jiao, Junze Zhang, Qiheng He, Ruolei Wu, Shuo Wang, Jizong Zhao, Junting Zhang, Jiguang Wang#, Yong Cao#
Stroke and Vascular Neurology 2023.

Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma

Yoonhee Nam*, Harim Koo*, Yingxi Yang*, Sang Shin*, Zhihan Zhu, Donggeon Kim, Hee Jin Cho, Quanhua Mu, Seung Won Choi, Jason K. Sa, Yun Jee Seo, Yejin Kim, Kyoungmin Lee, Jeong-Woo Oh, Yong-Jun Kwon, Woong-Yang Park, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Chul-Kee Park, Hye Won Lee#, Yeup Yoon#, Jiguang Wang#
Genome Medicine, volume 15, Article number: 16 (2023)

Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation

Ran Huo*, Yingxi Yang*, Yingfan Sun*, Qiuxia Zhou, Shaozhi Zhao, Zongchao Mo, Hongyuan Xu, Jie Wang, Jiancong Weng, Yuming Jiao, Junze Zhang, Qiheng He, Shuo Wang, Jizong Zhao, Jiguang Wang#, Yong Cao#
Angiogenesis, Volume 26, issue 2, May 2023

scONE-seq: A one-tube single-cell multi-omics method enables simultaneous dissection of molecular phenotype and genotype heterogeneity from frozen tumors

Lei Yu, Xinlei Wang, Quanhua Mu, Sindy Tam, Danson Loi, Aden Chan, Wai Sang Poon, Ho-Keung Ng, Danny Chan, Jiguang Wang, Angela Wu#.
Science Advances, VOL.9, Issue.1.

MET fusions and splicing variants convergently define a subgroup of glioma sensitive to MET inhibitors

KeNan Zhang, Zheng Zhao, Jing Chen, Zhaoshi Bao, RuiChao Chai, Zhiyan Sun, Lingxiang Wu, Zhiliang Wang, Hanjie Liu, Quanhua Mu, Huimin Hu, Fan Zeng, Zheng Wang, Guanzhang Li, Yuanhao Chang, Qiangwei Wang, Fan Wu, Ying Zhang, Yuqing Liu, Chunjie Jiang, Ulf Dietrich Kahlert, DoHyun Nam, Wei Zhang, Chunsheng Kang, Jiguang Wang, Rongjie Tao, Qianghu Wang, Tao Jiang
Holistic Integrative Oncology (2022) 1:18

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Xu Wang, Chao Yang, Xuejie Wang, Jinmin Miao, Weitao Chen, Yiren Zhou, Ying Xu, Yongyan An, Aifang Cheng, Wenkang Ye, Mengxian Chen, Dong Song, Xue Yuan, Jiguang Wang, Peiyuan Qian, Angela Ruohao Wu, Zhong-Yin Zhang, Kai Liu
Neuron, 11 November 2022.

Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability

Shubin Hong, Yubin Xie, Zhen Cheng, Jie Li, Weiman He, Zhuming Guo, Quan Zhang, Sui Peng, Minghui He, Shuang Yu, Lixia Xu, Rengyun Liu, Tianyi Xu, Yunjian Zhang, Yanbing Li, Jiguang Wang, Weiming Lv, Jun Yu, Haipeng Xiao
Oncogene. 2022 Oct 17:1-2.

Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asian populations

Zongchao Mo, Junyi Xin, Ruichao Chai, Peter Y.M. Woo, Danny T.M.Chan, Jiguang Wang
Cancer Biol Med. 2022 Oct 15; 19(10): 1440–1459.

Clinical management and survival outcomes of patients with different molecular subtypes of diffuse gliomas in China (2011–2017): a multicenter retrospective study from CGGA

Kenan Zhang, Xing Liu, Guanzhang Li, Xin Chang, Shouwei Li, Jing Chen, Zheng Zhao, Jiguang Wang, Tao Jiang, Ruichao Chai
Cancer Biol Med. 2022 Oct 15; 19(10): 1460–1476.

Machine learning of genomic features in organotropic metastases stratifies progression risk of primary tumors

Biaobin Jiang, Quanhua Mu, Fufang Qiu, Xuefeng Li, Weiqi Xu, Jun Yu, Weilun Fu, Yong Cao, Jiguang Wang#.
Nature Communications, 12, 6692, 2021.
This manuscript was posted on Research Square on Seq 18, 2020. https://doi.org/10.21203/rs.3.rs-73390/v1

De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation

Hao Li*, Yoonhee Nam*, Ran Huo*, Weilun Fu*, Biaobin Jiang, Qiuxia Zhou, Dong Song, Yingxi Yang, Yuming Jiao, Jiancong Weng, Zihan Yan, Lin Di, Jie Li, Jie Wang, Hongyuan Xu, Shuo Wang, JiZong Zhao, Zilong Wen, Jiguang Wang#, Yong Cao#.
Circulation Research, 129(9), 825–839, 2021.
Yoonhee Nam has been featured at "Meet the First Authors"
Highlighted at the Cover of Volume 129, Issue 9 of Circulation Research.

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution.

Bao, Zhaoshi; Wang, Yongzhi; Wang, Qiangwei; Fang, Shengyu; Shan, Xia; Wang, Jiguang; Jiang, Tao.
Frontiers of Medicine, 24 April 2021.

Somatic MAP3K3 mutation Defines a Subclass of Cerebral Cavernous Malformation.

Jiancong Weng*, Yingxi Yang*, Dong Song*, Ran Huo*, Hao Li, Yiyun Chen, Yoonhee Nam, Qiuxia Zhou, Yuming Jiao, Weilun Fu, Zihan Yan, Jie Wang, Hongyuan Xu, Lin Di, Jie Li, Shuo Wang, Jizong Zhao, Jiguang Wang#, Yong Cao#.
American Journal of Human Genetics, 108, 5, 2021.

DeepDRK: a deep learning framework for drug repurposing through kernel-based multi-omics integration

Yongcui Wang#, Yingxi Yang, Shilong Chen, Jiguang Wang#.
Briefings in Bioinformatics, 22, 5, 2021.

Classifying gastric cancer using FLORA reveals clinically-relevant molecular subtypes and highlights LINC01614 as a biomarker for patient prognosis

Yiyun Chen*, Wing Yin Cheng*, Hongyu Shi*, Shengshuo Huang, Huarong Chen, Dabin Liu, Weiqi Xu, Jun Yu#, Jiguang Wang#.
Oncogene, 40, 2898–2909, 2021.

Patient-Derived Nasopharyngeal Cancer Organoids for Disease Modelling and Radiation Dose Optimization

Sasidharan Swarnalatha Lucky*, Martin Law, Ming Hong Lui, Jamie Mong, Junli Shi, Sidney Yu, Do Kun Yoon, Shih Kien Djeng, Jiguang Wang, Chwee Ming Lim, Min Han Tan.
Front. Oncol., 11, 2021.

EmPC-Seq: Accurate RNA-sequencing and Bioinformatics Platform to Map RNA Polymerases and Remove Background Error

Yuqing Wang*, Tin Hang Chong*, Ilona Christy Unarta*, Xinzhou Xu, Gianmarco D. Suarez, Jiguang Wang, John T. Lis, Xuhui Huang, Peter Pak-Hang Cheung#.
Bio-protocol, 11.4, e3921-e3921, 2021.

Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells

Brice Laffleur*, Junghyun Lim*, Wanwei Zhang*, Yiyun Chen, Evangelos Pefanis, Jonathan Bizarro, Carolina R. Batista, Lijing Wu, Aris N. Economides, Jiguang Wang, Uttiya Basu#.
Nature genetics, 53.2, 230-242, 2021.

Alternative splicing of three genes encoding mechanotransduction-complex proteins in auditory hair cells

Zijing Zhou, Xiaojie Yu, Biaobin Jiang, Wanying Feng, Ye Tian, Zhiyong Liu, Jiguang Wang, Pingbo Huang#.
eNeuro, 0381-20, 2020.

Clinical practice guidelines for the management of adult diffuse gliomas

Tao Jiang#, Do-Hyun Nam#, Zvi Ram#, Wai-sang Poon#, Jiguang Wang#, Damdindorj Boldbaatar#, Ying Mao#, Wenbin Ma#, Qing Mao#, Yongping You#, Chuanlu Jiang#, Xuejun Yang#, Chunsheng Kang, Xiaoguang Qiu, Wenbin Li, Shaowu Li, Ling Chen, Xuejun Li, Zhixiong Liu, Weimin Wang, Hongmin Bai, Yu Yao, Shouwei Li, Anhua Wu, Ke Sai, Guilin Li, Kun Yao, Xinting Wei, Xianzhi Liu, Zhiwen Zhang, Yiwu Dai, Shengqing Lv, Liang Wang, Zhixiong Lin, Jun Dong, Guozheng Xu, Xiaodong Ma, Wei Zhang, Chuanbao Zhang, Baoshi Chen, Gan You, Yongzhi Wang, Yinyan Wang, Zhaoshi Bao, Pei Yang, Xing Fan, Xing Liu, Zheng Zhao, Zheng Wang, Yiming Li, Zhiliang Wang, Guanzhang Li, Shengyu Fang, Lianwang Li, Yanwei Liu, Shuai Liu, Xia Shan, Yuqing Liu, Ruichao Chai, Huimin Hu, Jing Chen, Wei Yan, Jinquan Cai, Hongjun Wang, Lingchao Chen, Yuan Yang, Yu Wang, Lei Han, Qixue Wang, on behalf of the Chinese Glioma Cooperative Group (CGCG), Society for Neuro-Oncology of China (SNO-China), Chinese Brain Cancer Association (CBCA), Chinese Glioma Genome Atlas (CGGA), Asian Glioma Genome Atlas (AGGA) network
499, 60-72, 2021.

CELLO: a longitudinal data analysis toolbox untangling cancer evolution

Biaobin Jiang*, Dong Song*, Quanhua Mu, Jiguang Wang#.
Quantitative Biology, 3, 256-266, 2020.

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

Barbara Oldrini*, Nuria Vaquero-Siguero*, Quanhua Mu*, Paula Kroon, Ying Zhang, Marcos Galán-Ganga, Zhaoshi Bao, Zheng Wang, Hanjie Liu, Jason Sa, Junfei Zhao, Hoon Kim, Sandra Rodriguez-Perales, Do-Hyun Nam, Roel Verhaak, Raul Rabadan, Tao Jiang#, Jiguang Wang#, Massimo Squatrito#.
Nat Commun, 11, 3883, 2020.
This manuscript was posted on biorxiv on March 11, 2020. doi: https://doi.org/10.1101/704486

Genomic characterization of HIV-associated plasmablastic lymphoma identifies pervasive mutations in the JAK-STAT pathway

Zhaoqi Liu, Ioan Filip, Karen Gomez, Dewaldt Engelbrecht, Shabnum Meer, Pooja Lalloo, Pareen Patel, Yvonne Perner, Junfei Zhao, Jiguang Wang, Laura Pasqualucci#, Raul Rabadan#, Pascale Willem#.
Blood Cancer Discovery, 1(1), 2020.

Structural basis for the high affinity interaction between CASK and Mint1

Wu, X.*, Cai, Q.*, Chen Y., Zhu S., Mi, J., Wang J., Zhang M.#.
Structure, 28(6), 664-673, 2020.

Identifying Transcription Error-Enriched Genomic Loci Using Nuclear Run-On Circular-Sequencing Coupled with Background Error Modeling

Cheung, P.*, Jiang, B.*, Booth, G.T., Chong, T.H., Unartar, I.C., Wang, Y., Suarez, G.D., Wang, J.#, Lis, J.T.#, Huang, X.#.
J. Mol. Biol., 432(13), 3933-3949, 2020.

Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization

Zhaoqi Liu, Akihide Yoshimi, Jiguang Wang, Hana Cho, Stanley Chun-Wei Lee, Michelle Ki, Lillian Bitner, Timothy Chu, Harshal Shah, Bo Liu, Anthony R. Mato, Peter Ruvolo, Giulia Fabbri, Laura Pasqualucci, Omar Abdel-Wahab, Raul Rabadan#.
Cancer Discovery, 10.6, 806-821, 2020.

A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets

Liu M, Yan Q, Sun Y, Nam Y, Hu L, Loong JH, Ouyang Q, Zhang Y, Li HL, Kong FE, Li L, Li Y, Li MM, Cheng W, Jiang L, Fang S, Yang X, Mo JQ, Gong YF, Tang YQ, Li Y, Yuan YF, Ma NF, Lin G, Ma S, Wang J, Guan XY.
PNAS, 117(11), 6103-6113, 2020.

Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination

Gerson Rothschild, Wanwei Zhang, Junghyun Lim, Pankaj Kumar Giri, Brice Laffleur, Yiyun Chen, Mingyan Fang, Yuling Chen,Lekha Nair, Zhi-Ping Liu, Haiteng Deng, Lennart Hammarström, Jiguang Wang , Uttiya Basu.
Science Immunology, 5(44), eaay5864, 2020.

A Mini-review on Spatiotemporal Evolution of Glioma Under Treatment

LUI Ming-Hong, JIANG Biao-Bin, BAO Zhao-Shi, WANG Jiguang#,
Prog. Biochem. Biophys., 46(11):1055~1062, 2019.

CNAPE: A Machine Learning Method for Copy Number Alteration Prediction from Gene Expression

Mu Quanhua, Wang Jiguang#
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 1-1, October, 2019.
This manuscript was posted on biorxiv on July 17, 2019. doi: https://doi.org/10.1101/704486

The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function

Ruth A. Singer, Luis Arnes, Yi Cui, Jiguang Wang, Yuqian Gao, Michelle A. Guney, Kristin E. Burnum Johnson, Raul Rabadan, Charles Ansong, Galya Orr, Lori Sussel#
Cell metabolism, 30(6), 1091-1106, 2019.

Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs

Mingxi Deng, Ying Wang, Lina Zhang, Yang Yang, Shengshuo Huang, JiguangWang, Hao Ge, Toyotaka Ishibashi, Yan Yan#
Development, 146(18), dev179754, 2019.

Hierarchical graphical model reveals HFR1 bridging circadian rhythm and flower development in Arabidopsis thaliana

Zhana Duren, Yaling Wang, Jiguang Wang, Xing-Ming Zhao, Le Lv, Xiaobo Li, Jingdong Liu#, Xin-Guang Zhu#, Luonan Chen# and Yong Wang#
NPJ Systems Biology and Applications, 5(1), 1-11, 2019.

Repurposing dasatinib for diffuse large B cell lymphoma

Claudio Scuoppo#, Jiguang Wang, Mirjana Persaud, Sandeep K. Mittan, Katia Basso, Laura Pasqualucci, Raul Rabadan, Giorgio Inghirami, Carla Grandori, Francesc Bosch, Riccardo Dalla-Favera#
PNAS, 116(34), 16981-16986, August 20, 2019.

Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors

Tiantian Ji*, Lina Zhang*, Mingxi Deng, Shengshuo Huang, Ying Wang, Tri Thanh Pham, Andrew Alan Smith, Varun Sridhar, Clemens Cabernard, Jiguang Wang, Yan Yan#
Disease Models and Mechanisms, 12(8), dmm040147, August 2019.

Deciphering Brain Complexity Using Single-cell Sequencing

Quanhua Mu*, Yiyun Chen*, Jiguang Wang#
Genomics, Proteomics & Bioinformatics, 17(4), 344-366, 2019.
Featured in News & Views:
24-12-2019: Top 3 most downloaded articles in last 3 months in GPB!

Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma

L X Xu, M H He, Z H Dai, J Yu, J G Wang, X C Li, B B Jiang, Z F Ke, T H Su, Z W Peng, Y Guo, Z B Chen, S L Chen, S Peng#, M Kuang#
Annals of oncology, 30(6), 990-997, 2019.

Comprehensive characterization of compartment specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma

Luis Arnes*#, Zhaoqi Liu*, Jiguang Wang*, H. Carlo Maurer, Irina sagalovisky, Marta Sanchez-Martin, Nikhil Bommakanti, Diana C. Garofalo, Dina A. Balderes, Lori Sussel, Kenneth P. Olive#, Raul Rabadan#
Gut, 68(3), 499-511, 2019 (Published online on 10 February, 2018).

Mutational landscape of secondary glioblastoma guides MET-targeted trial in brain tumor

Huimin Hu*, Quanhua Mu*, Zhaoshi Bao*, Yiyun Chen*, Yanwei Liu*, Jing Chen, Kuanyu Wang, Zheng Wang, Yoonhee Nam, Biaobin Jiang, Jason K. Sa, Hee-Jin Cho, Nam-Gu Her, Chuanbao Zhang, Zheng Zhao, Ying Zhang, Fan Zeng, Fan Wu, Xun Kang, Yuqing Liu, Zenghui Qian, Zhiliang Wang, Ruoyu Huang, Qiangwei Wang, Wei Zhang, Xiaoguang Qiu, Wenbin Li, Do-Hyun Nam, Xiaolong Fan#, Jiguang Wang#, Tao Jiang#
Cell, 175(6), 1665-1678, 2018.
Featured in News & Views: A Brain-Penetrant MET Inhibitor Achieves Responses in Glioblastoma

Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy

Jin-Ku Lee*, Zhaoqi Liu*, Jason K. Sa*, Sang Shin*, Jiguang Wang*, Mykola Bordyuh, Hee Jin Cho, Oliver Elliott, Timothy Chu, Seung Won Choi, Daniel I. S. Rosenbloom, In-Hee Lee, Yong Jae Shin, Hyun Ju Kang, Donggeon Kim, Sun Young Kim, Moon-Hee Shim, Jusun Kim, Taehyang Lee, Yun Jee Seo, Hyemi Shin, Mijeong Lee, Sung Heon Kim, Yong-Jun Kwon, Jeong-Woo Oh, Minsuk Song, Misuk Kim, Doo-Sik Kong, Jung Won Choi, Ho Jun Seol, Jung-Il Lee, Seung Tae Kim, Joon Oh Park, Kyoung-Mee Kim, Sang-Yong Song, Jeong-Won Lee, Hee-Cheol Kim, Jeong Eon Lee, Min Gew Choi, Sung Wook Seo, Young Mog Shim, Jae Ill Zo, Byong Chang Jeong, Yeup Yoon, Gyu Ha Ryu, Nayoung K.D. Kim, Joon Seol Bae, Woong-Yang Park, Jeongwu Lee, Roel G. W. Verhaak, Antonio Iavarone, Jeeyun Lee#, Raul Rabadan#, Do-Hyun Nam#
Nature Genetics, 50(10), 1399-1411, 2018.
Featured in News & Views: Cancer cell lines as patient avatars for drug response prediction

GeneCT: a generalizable cancerous status and tissue origin classifier for pan-cancer biopsies

Kun Sun, Jiguang Wang, Huating Wang and Hao Sun
Bioinformatics, 34(23), 4129-4130, 2018.

Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma

Patrick J. Cimino, Youngmi Kim, Hua-Jun Wu, Jes Alexander, Hans-Georg Wirsching, Frank Szulzewsky, Ken Pitter, Tatsuya Ozawa, Jiguang Wang, Julio Vazquez, Sonali Arora, Raul Rabadan, Ross Levine, Franziska Michor and Eric C. Holland
Genes & Dev, 32(7-8), 512-523, 2018.

Genetic Landscape of Ultra-Stable Chronic Lymphocytic Leukemia Patients

S. Raponi*, I. Del Giudice*, M. Marinelli, J. Wang, L. Cafforio, C. Ilari, A. Piciocchi, M. Messina, S. Bonina, S. Tavolaro, M. Bordyuh, P. Mariglia, N. Peragine, F.R. Mauro, S. Chiaretti, S. Molica, M. Gentile, A. Visentin, L. Trentin, G.M. Rigolin, A. Cuneo, F. Diop, D. Rossi, G. Gaidano, A. Guarini, R. Rabadan, R. Foà
Annals of Oncology, 29(4), 966-972, 2018.

Refined karyotype-based prognostic stratification of chronic lyphocytic leukemia with a low and very-low risk genetic profile

Ilaria Del Giudice, Gian Matteo rigolin, Sara Raponi, Luciana Cafforio, Caterina Ilari, Mykola Bordyuh, Jiguang Wang, Alfonso Piciocchi, Marilisa Marinelli, Mauro Nanni, Simona Tavolaro, Marco Filetti, Antonella Bardi, Elisa Tammiso, eleonora volta, Massimo Negrini, Elena Saccenti, Francesca Mauro, Davide Rossi, Gianluca Gaidano, Anna Guarini, Raul Rabadan, Antonio Cuneo, and Robin Foà
Leukemia 32(2), 543-546, 2018.

RNA exosome complex-mediated control of redox status in pluripotent stem cells

Maria Skamagki, Cheng Zhang, Christian A. Ross, Aparna Ananthanarayanan, Zhong Liu, Quanhua Mu, Uttiya Basu, Jiguang Wang, Rui Zhao, Hu Li, Kitai Kim#
Stem cells reports, 9(4): p1053–1061, 2017.

Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas

Chioma J Madubata*, Alireza Roshan-Ghias* , Timothy Chu, Samuel Resnick, Junfei Zhao, Luis Arnes, Jiguang Wang# & Raul Rabadan#
NPJ Genomic Medicine, 2(1), 29, 2017.

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function

Hyunju Oh, Yenkel Grinberg-Bleyer, Will Liao, Dillon Maloney, Pingzhang Wang, Zikai Wu, Jiguang Wang, Dev M.Bhatt, Nicole Heise, Roland M. Schmid, Matthew S. Hayden, Ulf Klein, Raul Rabadan, Sankar Ghosh
Immunity, 47(3), 450-465, 2017.

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

Jin-Ku Lee*, Jiguang Wang*, Jason K Sa*, Erik Ladewig*, Hae-Ock Lee, In-Hee Lee, Hyun Ju Kang, Daniel S Rosenbloom, Pablo G Camara, Zhaoqi Liu, Patrick van Nieuwenhuizen, Sang Won Jung, Seung Won Choi, Junhyung Kim, Andrew Chen, Kyu-Tae Kim, Sang Shin, Yun Jee Seo, Jin-Mi Oh, Yong Jae Shin, Chul-Kee Park, Doo-Sik Kong, Ho Jun Seol, Andrew Blumberg, Jung-Il Lee, Antonio Iavarone, Woong-Yang Park, Raul Rabadan & Do-Hyun Nam
Nature Genetics, 49(4), 594-599, 2017.

Jiguang Wang, Emanuela Cazzato, Erik Ladewig, Veronique Frattini, Daniel I S Rosenbloom, Sakellarios Zairis, Francesco Abate, Zhaoqi Liu, Oliver Elliott, Yong-Jae Shin, Jin-Ku Lee, In-Hee Lee, Woong-Yang Park, Marica Eoli, Andrew J Blumberg, Anna Lasorella, Do-Hyun Nam, Gaetano Finocchiaro, Antonio Iavarone & Raul Rabadan
Nature Genetics, 48(7), 768-776, 2016.

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
Kenta Yamamoto, Jiguang Wang, Lisa Sprinzen, Jun Xu, Christopher J Haddock, Chen Li, Brian J Lee, Denis G Loredan, Wenxia Jiang, Alessandro Vindigni, Dong Wang, Raul Rabadan & Shan Zha
eLife, 5, e14709, 2016.

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
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Cell, 164(3), 550-563, 2016.

Network Propagation Reveals Novel Features Predicting Drug Response of Cancer Cell Lines
Jiguang Wang, Judith Kribelbauer & Raul Rabadan
Current Bioinformatics, 11(2), 203-210, 2016.

Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes
Monica Messina*, Sabina Chiaretti*, Jiguang Wang*, Anna Lucia Fedullo, Nadia Peragine, Valentina Gianfelici, Alfonso Piciocchi, Fulvia Brugnoletti, Filomena Di Giacomo, Simona Pauselli, Antony B. Holmes, Maria Cristina Puzzolo, Giulia Ceglie, Valerio Apicella, Marco Mancini, Geertruy te Kronnie, Anna Maria Testi, Antonella Vitale, Marco Vignetti, Anna Guarini, Raul Rabadan & Robin Foà
Oncotarget, 7(12), 13886-13901, 2016.