Jiguang Wang (王吉光)

Padma Harilela Associate Professor of Life Science

Division of Life Science
Department of Chemical and Biological Engineering
Center for Systems Biology and Human Health
State Key Laboratory of Molecular Neuroscience
Hong Kong University of Science and Technology (HKUST)


Office 5577, Academic Building
Hong Kong University of Science and Technology (HKUST)
Clear Water Bay, Kowloon
Hong Kong Special Administrative Region, China

Tel: +852 3469 2672

E-mail: echo khxboh@vtu.il | tr '[b-{]' '[a-z]'


Biography

Prof. Wang received his Ph.D. in Applied Mathematics from Academy of Mathematics and Systems Science, Chinese Academy of Sciences (CAS), and won the Special Prize of President Scholarship and Excellent PhD thesis Award of CAS. Between 2011 and 2015, he was a Postdoctoral Research Scientist at Columbia University. From 2015, he was named as the Precision Medicine Fellow and promoted to an Associate Research Scientist. He established the Wang Genomics Laboratory @HKUST in 2016, focusing on the application of data science in biology and medicine. He has made substantial contributions to (1) characterization, modelling, and prediction of cancer evolution from genomics (Nat Genet 2016; Nat Genet 2017; Nat Commun 2021); (2) discovery, elucidation, and clinical application of MGMT fusion (Nat Genet 2016; Nat Commun 2020) and METex14 in adult gliomas (Nat Genet 2018; Cell 2018); (3) Discovery of MAP3K3-I441M in CCM (AJHG 2021) and elucidation of EndMT in bAVM (Circ Res 2021); (4) reconstruction of RNA Exosome-regulated non-coding transcriptomes (Nature 2014; Cell 2015). He won the Excellent Young Scientist Award of NSFC (2019), School of Engineering Young Investigator Research Award (2019), School of Science Research Award (2021), and the Zhong Nanshan Youth Science and Technology Innovation Award (2021).

Research Questions

Recent advances in next-generation sequencing are revolutionizing numerous areas in life science and medicine. My research is focused on discovering and elucidating functional genomic alterations in complex human diseases, such as intracranial cancers and vascular malformations, by developing and/or applying computational methods based on multi-omics integration, statistics, and machine learning, aiming to bridge the gaps among data, bench, and bedside. More specifically, my team has been mainly working on the following two scientific questions.

EXPERIENCE

HONORS AND AWARDS

PUBLICATIONS



  • Invited speaker, 第五届基因测序网络大会, online, 5 July, 2022


  • Invited speaker, Xian Nong Tan Forum for Medicine (34), 中国医学科学院药物研究所, online, 26 June, 2022


  • Invited speaker, 广东省人民医院, 17 June, 2022


  • Invited speaker, 浙江大学附属湖州市中心医院-人工智能与医学影像专题沙龙,online, 11 June, 2022


  • Invited speaker, NSFC/RGC Workshop on Single-Cell Data Science, HKU, online, 2 June, 2022


  • Invited speaker, 类脑研究院“脑科学与类脑智能” 校庆117周年暨第56届科学报告讨论会, 复旦, online, 27 May, 2022


  • Invited speaker, FASEB Advanced Catalyst Conference, online, 14 April 2022


  • Invited speaker, Brain 2022, online, 26 Feb 2022


  • Invited speaker, 2021 POST-SABCS Guangzhou, online via Zoom, 11 December 2021


  • Invited speaker, SKL IAB meeting, 20 July 2021


  • Invited speaker, HKUST Faculty Recognition Ceremomy, 13 July 2021


  • Invited speaker, CUHK surgery, 10 May 2021


  • Invited speaker, 全国生物信息云论坛, Online, 16 January 2021


  • Invited speaker, Online talk on GBM evolution, CUHK, Hong Kong, 18 December 2020


  • Invited speaker, ICSA 2020 Applied Statistics Symposium, Online, 15 December 2020


  • Invited speaker, Renmin Hospital of Guangdong province, Guangzhou, 26 November 2020


  • Invited speaker for LIFS, HKUST, Hong Kong, 30 October 2020


  • Invited speaker for 京脑重大疾病研究院-他山之玉论坛-脑重大疾病基础研究临床转化系列讲座, Online, 6 October 2020


  • Invited speaker at CBET Technological Workshop in CUHK, 30 July 2020


  • Invited speaker at 运筹千里纵横论坛(第八期) at TencentMeeting, 21 June 2020


  • Invited speaker at 湖北省医学会放射学分会2019学术年会 in Wuhan, 23 November 2019


  • Invited speaker at Southern Medical University in Guangzhou, 18 November 2019


  • Invited speaker at Southern University of Science and Technology in Shenzhen, 15 November 2019


  • Contributed talk at OIST, the 20th International Conference on Systems Biology in The Okinawa Institute of Science and Technology Graduate University (OIST), 1 - 5 November 2019


  • Invited speaker at Wuhan University School of Basic Medical Sciences in Wuhan, 23 September 2019


  • Invited speaker in 第一届全国系统生物学大会 on “复发脑胶质母细胞瘤遗传学图谱研究及临床应用” at Shanghai Jiaotong University, 21 September 2019


  • Invited speaker at Nanfang Hospital in Guangzhou, 17 August 2019


  • Invited speaker at Wuhan University School of Basic Medical Sciences in Wuhan, 15 August 2019


  • Invited speaker at IBW2019: The Fourteenth International Bioinformatics Workshop in Beijing, 4 August 2019


  • Invited speaker at Gordon Research Conference on Translational Cancer Genomics - Multiomics-Based Cancer Molecular Typing, Prognostication and Treatment, Regal Riverside Hotel, 30 June 2019


  • Invited speaker by The 9th International Workshop on Cancer System Biology at Japan Union Hospital, Jilin University, Changchun, China, 29 June 2019


  • Invited speaker in Institute of Neuroscience Seminar at Institute of Neuroscience, Shanghai Institute for Biological Sciences, CAS, 21 June 2019


  • Invited speaker at Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, 20 June 2019


  • Invited speaker in 第七届“数学,计算机与生命科学交叉研究”青年学者论坛 at Academy of Mathematics and Systems Science, Chinese Academy of Sciences, 19 May 2019


  • Invited speaker in School of Biomedical Sciences Research Day 2019 at The Chinese University of Hong Kong, 16 May 2019


  • Invited speaker in 2019年第三届复旦大学附属肿瘤医院肝胆外科专家论坛 at Shanghai Marriott Hotel Parkview, 12 Apr 2019


  • Invited speaker in 系统生物学院重点实验室国际杰出科学家系列讲座 at Key Laboratory of Systems Biology, CAS, Shanghai Institutes for Biological Sciences, 11 April 2019


  • Invited speaker in SNO China, 15 Mar 2019


  • Invited speaker in HKUST-Tsinghua University Joint Symposium on Life Science at IAS, HKUST, 15 Jan 2019


  • Invited speaker in at Academy of Mathematics and Systems Science, CAS, 29 Dec 2018


  • Invited speaker at Department of CS, CUHK, 14 Dec 2018


  • Invited speaker at Shandong University, 26 Dec 2018


  • Invited speaker at Xiamen University, 24 Dec 2018


  • Invited speaker in HKUST-Yale University Joint Symposium of Life Science and Quantitative biology at LTF, HKUST, 15 Dec 2018


  • Invited speaker at Big Data Challenges for Predictive Modeling of Complex Systems, HKU, 29 Nov 2018


  • Invited Speaker at Peking University, 26 Nov, 2018


  • Invited Speaker at 1st hospital, SUN YAT-SEN UNIVERSITY, Guangzhou, China, 25 Nov 2018


  • Contributed speaker, SNO 2018


  • Co-organizer and speaker, IAS focused program on New Technologies and Translational Applications in Genomics, Nov 7-9 2018


  • Invited speaker RNA club, City U, Hong Kong, 6 Nov 2018


  • Invited speaker LIFS student seminar, HKUST, 2 Nov 2018


  • Invited speaker at ICG13, Shenzhen, 27 Oct 2018


  • Invited speaker at Lunch for Science (Smart diagnosis), HKUST, 24 Oct 2018


  • Session Organizer and Speaker of Max Planck-Croucher Symposium 2018: The Future of Biology, Schloss Ringberg, Germany, 20-23 May 2018


  • Invited speaker in JMCB Symposium 2018, Shanghai, China, 8-10 June 2018


  • Session Organizer and Speaker of Max Planck-Croucher Symposium 2018: The Future of Biology, Schloss Ringberg, Germany, 20-23 May 2018


  • Invited speaker in a multidisciplinary symposium at City University of Hong Kong, Hong Kong, China, 26 April 2018


  • Session Organizer and Speaker in the 1st AsiaEvo Conference, Shenzhen, China, 20 April 2018


  • Invited Speaker in the China Society of Biotechnology Young Scientists Forum III, Tianjin, China, 14 April 2018


  • Invited Speaker in HKUST-CSRC Joint Workshop on Computational Science, Beijing, China, 30 March 2018


  • invited Speaker at the 2nd annual meeting of Society for Neuro-Oncology of China at Changsha, China, 16 March 2018


  • invited speaker at Brain 2018, 20 January 2018


  • Invited Speaker at South China University of Technology, Guangzhou, China, 25 December 2017


  • Invited Speaker at Department of Chemical Pathology, CUHK, 15 December 2017


  • Co-organizer and Speaker on The Kick-off meeting of AGGA, Beijing, China, 10-11 November 2017


  • Invited Speaker at BGI, Shenzhen, China, 23 October 2017


  • Invited Speaker the second meeting of the Asian Glioma Genome Atlas, SMC, Korea, 19-21 October, 2017


  • Invited Speaker at SCC seminar, HKUST, Hong Kong, China, 22 October 2017


  • Invited Speaker at Beijing Institue of Genomics, Beijing, China, 4 September 2017


  • Invited Speaker in Second Symposium on Frontiers of Soft Matter Science and Engineering Youth Forum on Biomacromolecules (CSMSE-2017), Peking University, Beijing, China, 2 September 2017


  • Invited Speaker in 第三届全国脑胶质瘤分子病理与综合治疗研讨会暨第一届中国医师协会脑胶质瘤专业委员会分子诊疗专业委员会学术大会, Beijing, China, 2 September 2017


  • Invited Speaker in 2017 International Symposium on Genomics and Regenerative Medicine, NSFC-HKUST, Hong Kong, China, 29 August 2017


  • Invited Speaker at The HK Epigenomics Meeting, HKUST, Hong Kong, China, 22 August 2017


  • Invited Speaker at The 11th International Conference on Computational Systems Biology (ISB 2017), Shenzhen, China, 19 August 2017


  • Invited Speaker at Institution of Stomatological Research, SUN YAT-SEN UNIVERSITY, Guangzhou, China, 25 July 2017


  • Invited Speaker at Northwest Institute of Plateau Biology, CAS, Xining, China, 18 July 2017


  • Invited Speaker at Shanghai Institutes for Biological Sciences, CAS, Shanghai, China, 14 July 2017


  • Invited Speaker at CUHK-SKL of Digestive Disease Research Meeting, CUHK, Hong Kong, China, 7 July 2017


  • Co-organizer and Speaker on The mini Symposium about AI in Brain Tumor Studies between BJNI and HKUST, BJNI, Beijing, China, 3-4 July 2017


  • Invited Speaker in The 13th Asia Pacific Multidisciplinary Meeting for Cancer Research, CUHK, Hong Kong, China, 22 June 2017


  • Invited Speaker at Symposium on Engineering Complex Genetic Systems: Approaches and Applications, HKU, Hong Kong, China, 9 June 2017


  • Invited Speaker in HKUST-Rice Mini-Symposium on Biomedical Science and Engineering, HKUST, Hong Kong, China, 7 June 2017


  • Organizer of the first meeting of the Asian Glioma Genome Atlas, HKUST, Hong Kong, 28 April-1 May 2017


  • Invited Speaker at Shenzhen Second People's Hospital, Shenzhen, China, 27 April 2017


  • Contributed Speaker in the China Society of Biotechnology Young Scientists Forum II, Guangzhou, China, 8 April 2017


  • Invited Speaker at Faculty of medicine school of biomedical sciences-Program in Cancer Biology and Experimental Therapeutics, CUHK, Hong Kong, China, 21 March 2017


  • invited Speaker at the 1st annual meeting of Society for Neuro-Oncology of China at China National Convention Center, Beijing, China, 19 March 2017


  • Invited speaker in the System Biology seminar, HKUST, Hong Kong, China, 4 March 2017


  • Invited speaker in the Discussion Forum between Engineering Schools of PKU and HKUST, HKUST, Hong Kong, China, 18 February 2017


  • invited speaker in the 8th Institute for Refractory Cancer Research International Symposium, Seoul, Korea, 13 January, 2017


  • Invited speaker at division seminar of Division of Life Science, HKUST, Hong Kong, China, 16 Dec 2016


  • Invited speaker in a one-day workshop on Quantitative Biology and Computational Health Sciences, Hong Kong, 14 Dec 2016


  • Contributed speaker in The Genomics of Common Diseases 2016, Baltimore, MD, USA, September 25-28, 2016


  • Contributed speaker in Systems Approaches to Cancer Biology Conference sponsored by the NCI, Woods Hole, MA, USA, April 3-6, 2016


  • Contributed speaker at The 10th International Symposium on Bioinformatics Research and Applications, Zhangjiajie, China, 2014


  • Contributed speaker at The 4th International Conference on Computational Systems Biology, Suzhou, China, 2010


  • Contributed speaker at The 3rd International Symposium on Optimization and Systems Biology, Zhangjiajie, China, 2009